As a result of dangers of dependancy, abuse and misuse, the bottom successful dose with the shortest duration consistent with specific affected individual therapy objectives really should be used.
Dosing mistakes have resulted from confusion in between mg and mL when prescribing, dispensing, and administering oral Answer; be certain that dose is communicated Obviously and dispensed correctly
Consider this medication precisely as prescribed to reduce the risk of dependancy. Ask your doctor or pharmacist for more details.
Overestimating the acetaminophen and codeine phosphate tablets dosage when converting sufferers from another opioid item can lead to a deadly overdose with the first dose.
Do not abruptly discontinue acetaminophen and codeine phosphate tablets inside of a individual bodily dependent on opioids. When discontinuing acetaminophen and codeine phosphate tablets inside a bodily dependent client, steadily taper the dosage.
Assess Each and every client’s risk for opioid dependancy, abuse, or misuse prior to prescribing acetaminophen and codeine phosphate tablets, and reassess all sufferers obtaining acetaminophen and codeine phosphate tablets for the event of such behaviors and situations. Pitfalls are greater in people with a personal or family members historical past of compound abuse (together with drug or alcohol abuse or addiction) or mental disease (e.g., key despair). The probable for these threats shouldn't, having said that, stop the right administration of suffering in almost any specified patient.
Due to the hazards of addiction, abuse and misuse, the bottom dose for your shortest period in line with particular person patient cure aims should be employed.
Concentration-Efficacy more info Relationships The minimal successful analgesic concentration will differ widely between sufferers, In particular amid patients who have already been Formerly treated with prolonged-release agonist opioids.
Patients need to comprehend this drug has most likely severe Uncomfortable side effects like adrenal insufficiency, extreme constipation, and hypotension, as well as perhaps considerable drug interactions, especially with other CNS depressants, which includes alcohol; sufferers must be instructed to speak with a Health care professional if any new signs or Uncomfortable side effects occur.
Instruct sufferers to not share acetaminophen and codeine phosphate tablets with Other folks and also to get actions to guard acetaminophen and codeine phosphate tablets from theft or misuse.
If concomitant use that has get more info a CYP2D6 inhibitor is critical, or if a CYP2D6 inhibitor is discontinued following concomitant use, consider dosage adjustment of acetaminophen website and codeine phosphate tablets and Appraise sufferers closely at Repeated intervals.
When get more info managing patients getting opioid analgesics, notably whoever has been handled an check here prolonged stretch of time, and/or with high doses for Serious suffering, ensure that a multimodal approach to pain administration, like mental well being guidance (if wanted), is in place ahead of initiating an opioid analgesic taper.
Inform sufferers not to just take acetaminophen and codeine phosphate tablets when employing any medication that inhibit monoamine oxidase. People shouldn't start MAOIs when taking acetaminophen and codeine phosphate tablets (see PRECAUTIONS, Drug Interactions).
When discontinuing acetaminophen and codeine phosphate tablets, steadily taper the dosage using a affected person-particular strategy that considers the following: the dose of acetaminophen and codeine phosphate tablets the affected person is having, the period of therapy, as well as Bodily and psychological attributes on the individual. To Enhance the likelihood of A prosperous taper and lower withdrawal indications, it can be crucial which the opioid tapering program is arranged through the affected person.